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Nausea, diarrhea, vomiting, and reduced appetite tend to peak during the first weeks of treatment and around dose increases

Iles, L

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Severely restricted food intake over extended periods can contribute to deficiencies that manifest as fatigue, cognitive impairment, bone health deterioration, and immune dysfunction

More research is needed to understand the mechanisms through which semaglutide produces these early clinical benefits, but they may include the drugs positive effects on reducing inflammation, blood sugar, blood pressure, direct effects on the heart and blood vessels, early dietary changes, or an interaction among these or other responses. Despite these important findings, the authors note that SELECT is not a trial looking to prevent first cardiovascular eventsall SELECT patients had a history of heart disease, placing them at high risk

Additionally, liraglutide shifted polarized macrophage phenotype in vitro from the pro-inflammatory M1 phenotype to the M2 anti-inflammatory phenotype