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The absence of a preexisting T2DM diagnosis, the absence of any previous antidiabetic drug, and prescribing outside of the benefit acted as surrogate markers for potential off-label prescribing of the GLP-1 RA brand with the indication of T2DM
Pharmaceutical interventions targeting this system aim to restore or augment pulsatile GH secretion while preserving the physiological feedback mechanisms that prevent sustained supraphysiologic GH exposure
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The FDA has not evaluated this product for therapeutic purposes