SGLT2is decrease plasma glucose levels by inhibiting renal reabsorption in the proximal tubule by increasing renal excretion of glucose
It is famous for supporting the immune system, but it is also vital for collagen synthesis
10.2337/db19-0138 Diabetes 54 WesterterpM.MurphyA.WangM.PaglerT
Signs of unhealthy weight loss Providers need to carefully monitor patients on GLP-1 medications, especially if they are losing too much weight too quickly, or reaching very low BMI levels
Furthermore, participants assigned to tirzepatide had a slower mean rate of decline in estimated glomerular filtration rate over the study period: 1.4 0.2 ml/min/1.73 m 2 body mass per year with tirzepatide compared with 3.6 0.2 ml/min/1.73 m 2 body mass per year with insulin glargine, for a between-group difference of 2.2 ml/min/1.73 m 2 body mass per year [95% CI 1.62.8 ml/min/1.73 m 2 body mass per year] [95]
Incretin-based drugs, such as semaglutide and liraglutide, produce clinically meaningful weight loss by reducing appetite and slowing gastric emptying