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The peptide altered 127 genes in these cells, upregulating repair genes while downregulating inflammatory pathways responsible for tissue destruction

Anti-inflammatory peptides like KPV may help control the inflammatory cascade that drives facet arthritis progression

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Regarding ferroptosis regulation, GGT-activated extracellular GSH catabolism produces iron-derived ROS, inducing lipid peroxidation via NF-B pathway activation (112)

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