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Incretins exert pleiotropic antidiabetic effects, including insulin secretion in response to glucose, diminished glucagon secretion, delayed gastric emptying, reduced hepatic glucose output, and increased pancreatic -cell survival (Jaiswal et al., 2022)

Therefore, long-term and persistent intervention with semaglutide is needed for the improvement of obesity

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Dietary management becomes particularly important when combining IBS with Wegovy