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Theres no specific trial yet of GLP-1 medications for AI-related joint pain, but the combination of structured exercise and gradual weight loss aligns with whats already shown to help
Weight-loss response depends on multiple factors, including genetics, baseline weight, medication adherence, dietary changes, physical activity, sleep quality, stress levels, and underlying health conditions
That's not what the disease is." Pressed on why someone shouldn't just order one online to shed a midlife spare tire, Kushner's honest answer isn't that it's dangerous so much as that it usually doesn't work the way people hope
To view or add a comment, sign in Can oxytocin promote weight loss without relying on brown fat nerve activation
Scientists have two other theories about how the drugs might help: by improving the insulin resistance common in people with NAFLD and lowering inflammation that can damage the liver
The standard protocol from the SUSTAIN trials (Marso et al., New England Journal of Medicine , 2016): Reduce basal insulin dose by 20% on the day you start semaglutide Monitor fasting blood glucose daily for the first 2 weeks Further reduce basal insulin by 10 to 20% if fasting glucose drops below 80 mg/dL or if hypoglycemia occurs Reduce mealtime (bolus) insulin by 20 to 30% during semaglutide titration, adjusting based on post-meal glucose readings Most patients on basal insulin end up reducing total daily insulin dose by 30 to 50% by the time they reach maintenance semaglutide dose
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