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Despite the benefits of GLP-1 RAs, subcutaneous administration is still a major barrier in adopting this therapy

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However, while Glucagon like-peptide 1 receptor (GLP-1R) agonists diminish appetite and may contribute to weight loss, the expression of GLP-1R in the gut of IBD patients is not known, or its functional relationship with the increased sensory and nociceptor innervation

They work by increasing insulin production, slowing digestion and promoting feelings of fullness, all of which help lower blood sugar, reduce appetite and lead to weight loss

That might not sound all that onerous, but peer-reviewed research shows it delays patients from getting the drugs their doctors say they need