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Based on converging evolutionary and mechanistic evidenceencompassing mitochondrial centrality in hypoxic response, natural selection of the Tibetan-enriched mitochondrial DNA haplogroup M9a, and bidirectional ROS-HIF regulatory crosstalkwe propose a mechanistic hypothesis that mitochondrial retrograde signaling orchestrates nuclear genomic reprogramming through modulation of HIF-responsive elements to establish hypoxia-tolerant phenotypes
Article Titles & Journals The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit c Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography im Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus
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Similar results were observed in an experiment involving a germ-free mouse strain, where the animals transplanted with microbiome isolated from depressed patients showed an increase in immobility time in the forced swim test and a decreased proportion of central motion distance in the open field test, compared to mice transplanted with bacteria obtained from healthy control subjects [101]
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