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Evidence-based management varies substantially depending on the specific autoimmune disorder, disease severity, organ involvement, and individual patient factors
Incretin-based multi-agonists, such as tirzepatide and retatrutide, target two or more receptors among GLP-1, GIP, and GCGR to enhance insulin secretion, improve fat metabolism, and increase energy expenditureultimately achieving greater weight loss and metabolic improvement
doi:10.1007/s11011-013-9376-4
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Clinically, both specific ferroptosis inhibitors (such as Ferrostatin-1) and traditional medicine components (such as Puerarin) have emerged as promising therapeutic candidates, showing cardioprotective effects in experimental models
Mounjaro was initially approved only to treat type 2 diabetes, but was granted approval by the MHRA (Medicines and Healthcare products Regulatory Agency) for use as a weight loss treatment in late 2023
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