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These cation-selective ligand-gated ion channels are activated by the excitatory neurotransmitter glutamate and mediate fast excitatory synaptic transmission in mammalian brains 1,2

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The UPR has three canonical branches (PERK/ATF4, IRE1a/XBP1, and ATF6), which play a central role in mitigating cellular stress by enhancing protein folding capacity and secretion, activating the oxidative stress response, and inducing autophagy, thereby restoring protein homeostasis (137)

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