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1) Weight reduction endpoints in obesity research protocols Retatrutide is widely referenced because the phase 2 obesity trial published in The New England Journal of Medicine reported substantial reductions in body weight over 48 weeks , with the highest dose groups reporting very large mean percentage reductions compared with placebo

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It posted the largest average weight loss ever reported in trials, roughly 28 percent at 80 weeks

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The GLP-1R/GIPR/GcgR triple-agonist retatrutide achieves body weight loss (~25%) in just two-thirds of the time, potentially surpassing the efficacy of Roux-en-Y gastric bypass [29]

After two weeks, Aetna approves it