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Its defining modification is a trans -3-hexenoyl group attached to the N-terminal tyrosine, a chemical change designed to protect the peptide from rapid cleavage by dipeptidyl peptidase-4 (DPP-4), the enzyme that quickly inactivates native GHRH

This action promotes the firing of layer V pyramidal neurons and stimulates glutamate release (Aleksandrova and Phillips, 2021), leading to excessive extracellular glutamate

Weight loss, often associated with GLP-1 drugs, can sometimes lead to changes in vitamin D levels

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