10.1016/j.biopha.2006.07.015 34 GamageA
Because oral glutathione is broken down significantly during digestion, injections are sometimes used to deliver it more directly
It is composed of three amino acids cysteine, glycine, and glutamate and is produced by the liver
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Pharmacologists call this a PK-PD disconnect, and it means a short half-life is not evidence of a short-lived effect, nor a long one evidence of a lasting one
In this case, the glutathione anion with a charge of -2 transfers an electron to the methylcobalamin structure at the very beginning of the CASSCF(14,13) geometry optimization, breaking the Co-C bond, similarly to the interaction of methylcob(II)alamin with the dissociated homocysteine anion [2, 96, 97]