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The useful analytical framework is to ask: what is the net present value of revenues the innovator can defend after patent expiry, given realistic lifecycle management success rates, biosimilar/generic competition timelines, and payer formulary dynamics
It affects your blood pressure, can cause severe GI symptoms, and can even lead to confusion, fevers, and seizuresin extreme cases, its life-threatening. The risk is very low for people who are just taking one medication, but if someone is on several medications that affect serotonin levels, the risk level rises
Still, having more options "could indeed impact the prescribing landscape," Dr
Another key strength is the study design, which minimized biases related to the inclusion of prevalent users without excluding patients with a history of self-harm or suicidal ideation
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