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Mitochondrial dysfunction, apoptosis and oxidative stress are in part due to methylglyoxal accumulation

For Zepbound: documented BMI with Z68 code, weight-related comorbidities, evidence of lifestyle intervention participation, and any prior weight management medication trials

Continuous use beyond 6 weeks leads to IGF-1 receptor downregulation (decreased density and sensitivity)

The LEADER and SOUL trials significantly reduced both fatal and non-fatal MI with liraglutide and semaglutide, respectively [14, 21]

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J., Li, Z