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Additionally, intraperitoneal injection of liraglutide reduced nociceptive behavior in the formalin test, particularly during the second phase [30]
While they may cause modest increases in heart rate (typically 2-4 beats per minute) and modest decreases in blood pressure, they do not significantly raise core body temperature or substantially accelerate metabolic rate
Mentias A, Aminian A, Youssef D, Pandey A, Menon V, Cho L, et al
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Although data on HR were not provided in most studies of twice-daily exenatide, HR elevation was generally more apparent in the GLP-1 RA treatment arms, compared with the comparator arms (Table 2)