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Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation
Age-related changes in renal function, hepatic metabolism, and tissue perfusion theoretically could influence peptide clearance and distribution, though no studies have systematically examined age effects
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In stark contrast, CJC-1295 has a half-life of 810 days
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