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Oxidative stress Oxidative stress is a pivotal mechanism behind ECD [99, 100], consisting of an imbalance of the redox state due to reactive oxygen species (ROS) overproduction, antioxidant systems depletion, or both

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Mechanistic Research Perspective Investigation of intracellular signaling pathway modulation Analysis of receptor-mediated peptide interaction mechanisms Evaluation of growth factor responsiveness in cellular systems Gene transcription and molecular regulation research Integration into mitochondrial ATP production and metabolic pathway studies Primary Research Applications Cell Biology and Regenerative Models: Used in controlled cellular models to study signalling behaviour, adaptive responses, and peptide-driven molecular communication

FIGURE 1 GSH: The main cofactor of system X c /GSH/GPX4 axis GSH is a core antioxidant that is formed by condensation of Glu, Cys, and Gly