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Key Takeaways Glutathione is a powerful antioxidant produced naturally in your cells, composed of three amino acids: glutamate, glycine, and cysteine

Glutathione depletion impairs virtually every aspect of immune cell activity.* Mitochondrial protection: Mitochondria maintain a dedicated mitochondrial glutathione (mGSH) pool that is critical for protecting mitochondrial DNA, inner membrane phospholipids, and electron transport chain components from the reactive oxygen species generated during oxidative phosphorylation.* Amino acid transport: Glutathione participates in the gamma-glutamyl cycle a metabolic pathway involved in amino acid transport across cell membranes and in the regulation of cellular glutathione biosynthesis.* Unique Verves S-Acetyl Glutathione in Clinical Context Laboratory research has documented that oral S-Acetyl Glutathione supplementation supports healthy total glutathione levels and healthy percent-reduced glutathione (the ratio of active GSH to oxidized GSSG) a clinically relevant biomarker of cellular redox status

For an excellent primer on what this process looks like, listen to Episode 127 of Resiliency Radio with Jim Tomlinson

Avoid use during acute infection or fever when protein metabolism is compromised

This enzyme participates in amino acid transport by transferring the -Glutamyl portion of glutathione to other amino acids, enabling them to cross cell membranes more easily

Aberrant mast cell activation (MCA) could mediate hyper-inflammation in COVID-19 and initiate severe cascades of immune responses that trigger allergic flare-ups in PASC 209