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Im managing a chronic disease and that chronic disease is not going away, so I may be on it for life. Critics of giving adolescents weight-loss medications also point to the lack of long-term data

There is no indication that using phentermine and semaglutide together has added weight loss benefits

doi:10.1007/s10549-025-07678-7 Lus C, Dias J, Firmino-Machado J, et al

GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism

2020 Jan 9;34(6):123747

Beginner's Guide to GLP-1 Nausea Relief: What Helps and What Makes It Worse Jennifer Hardy Jun 25, 2025 11 min read Updated: Jul 17, 2025 You're not alone in wondering how to reduce nausea on GLP-1s like Ozempic, Wegovy, or Zepbound