glp 1 cardiac benefit Stopping GLP-1 drugs can quickly erase cardiovascular benefits – WashU Medicine GLP-1 RAs: Beyond Glycemic Control

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Hydration status significantly affects periorbital appearance with dehydration exaggerating dark circles through increased blood viscosity pooling more visibly, skin dullness from reduced cellular hydration making circles more prominent, and impaired lymphatic function allowing fluid retention despite overall dehydration

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The trade-off is that the anabolic effect is more subtle and takes longer to manifest

According to FDA guidance, GLP-1 medications are not recommended for people who have: Pregnancy, because safety data are limited and pregnancy requires appropriate weight gain and nutrient storage A prior history of pancreatitis, due to a risk of triggering inflammation of the pancreas A history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2), a rare genetic condition linked to thyroid cancer in animal studies A clinician will review your medical history carefully to determine whether these medications are appropriate for you