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Lipid peroxidation is associated with the development of many neurodegenerative disorders, including Alzheimers disease (AD), Parkinsons disease (PD), and amyotrophic lateral sclerosis (ALS), all of which show elevated levels of lipid peroxidation
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This pathway provides a lipid radical-trapping mechanism at the plasma membrane (88, 89), thereby limiting lipid peroxidation
In current clinical practice, the GLP-1 receptor agonists with approved indications for the treatment of pediatric obesity are liraglutide and semaglutide
Oral administration and lipid metabolism
In addition, the application of exendin-4, a GLP-1RA in obese mice triggered by diet restores C1q/TNF-related protein 3 (CTRP3) expression in keratinocytes, thereby inhibiting STAT3 phosphorylation via lysosomal-associated membrane protein 1 (LAMP1) and alleviating the psoriatic symptoms induced by imiquimod treatment [204]
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