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Mechanism of Action: 2 adrenoreceptor agonist Peripheral : 2 agonists can directly cause arterial vasoconstriction , which can cause an initial phase of hypertension , before centrally mediated effects predominate, resulting in reduced sympathetic outflow from the CNS, which results in both bradycardia and hypotension (Malayala et al, 2022

If you are comparing this to other GLP-1 receptor agonists, our semaglutide vs tirzepatide comparison breaks down how dosing differs between the two

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