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Novel propargyl-linked bisubstrate analogues as tight-binding inhibitors for nicotinamide N-methyltransferase

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

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[72] reported that ferroptosis occurs in a mouse model of APAP-induced acute liver failure, showing elevated lipid peroxides derived from n -6 PUFAs

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Secondary endpoints included pharmacokinetic parameters and preliminary pharmacodynamic effects