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A total of 1,961 adult participants with a BMI of at least 30 or at least 27 with at least one weight-related comorbidity were randomized to receive either semaglutide (2.4 mg) or placebo, administered subcutaneously once weekly, along with lifestyle intervention

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Finally, our studies provide important insights for efforts aimed at development of therapeutic interventions designed to inhibit dietary L-carnitine conversion into TMAO in humans. References: l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans