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20 : 19 Taglialatela G, Navarra D, Cruciani R, Ramacci MT, Alema GS, Angelucci L
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Pure GLP-1 receptor agonists work through four mechanisms: Slowed gastric emptying (the primary satiety signal) Increased insulin secretion in response to glucose Reduced glucagon secretion (glucagon raises blood sugar) Central appetite suppression via hypothalamic GLP-1 receptors The weight loss ceiling for pure GLP-1 agonists appears to be around 15% to 17% of baseline body weight at maximum tolerated dose over 68 weeks (the STEP 1 and STEP 5 trial endpoints for semaglutide 2.4 mg)
Antibiotics promote the sampling of luminal antigens and bacteria via colonic goblet cell associated antigen passages
Hamedani M, Mirshafiey A, Vatanpour H, Khorramizadeh MR, Saadat F, Berahmeh A, Hadji-Ghasemi F
