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Do not double up on doses to make up for a missed one, as this could increase the risk of potential side effects
Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Stambolija V, Zoricic Z, Vrcic H, Sebecic B
Storing a vial on its side or inverted keeps the solution in sustained contact with the rubber stopper, which pharmaceutical literature describes as a potential leachable-contamination pathway over extended periods
D-Retro-Inverso (DRI) modification addresses this by: using D-amino acids (mirror images of natural L-amino acids) and reversing the sequence
Similar changes in membrane structure have been reported for short chain alcohols [357, 358] with a dependence on the alcohol concentration and chain length [359]
Acknowledgements This work was supported by the National Key Research and Development Program of China (2021YFF1000601), the National Natural Science Foundation of China (32172700) and the Joint Funds of the National Natural Science Foundation of China (U20A2052), and the Fundamental Research Funds for the Central Universities (grant number 2662018PY043)
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