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The study was approved by the ethical committee of Karolinska Institutet (616/03) and informed consent was obtained from the patients(or their parents)

Before infiltration, the bacterial suspension carrying different constructs was adjusted to a final OD 600 = 0.6

Previous studies in mouse models have demonstrated that MC4R deficiencyparticularly when combined with MC3R or LDL-receptor lossexacerbates metabolic disturbances, resulting in marked hypercholesterolemia with elevated LDL and very low-density lipoprotein fractions, as well as triglycerides, thereby fostering a pro-atherogenic lipid profile [94, 95]

Today, however, emerging metabolic therapiesespecially GLP-1 receptor agonistsare reshaping the conversation

Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-1 siRNA attenuates renal inflammation and fibrosis

Weight loss compounds present a fundamental problem: they typically require much larger doses to be effective than can realistically be delivered through the skin