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At t = 4 h, cells were serum starved and at t = 1 h, pre-treated with vehicle, control IgG1, or L2-Cmu (100 g/mL)

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Databases searched (and their content coverage dates) were Ovid MEDLINE(R) (1946+ including epub ahead of print, in-process, and other nonindexed citations), Ovid Embase (1974+), Ovid APA PsycInfo (1967+), Ovid Cochrane Central Register of Controlled Trials (1991+), Ovid Cochrane Database of Systematic Reviews (2005+), Web of Science Core Collection via Clarivate Analytics (1975+), and Scopus via Elsevier (1974+)

J Diabetes Investig, 2021

When IGF-1 LR3 binds to its receptor, it triggers a cascade that activates mTOR, the master regulator of protein synthesis in cells