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Several factors can contribute to perceived treatment failure

The evidence suggests yes

The contraindication screen, the labs, the medication review, all of it only happens because a clinician has to be involved

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You reconstitute less frequently, which means fewer opportunities for contamination or reconstitution error

Often this is due to inadequate nutrition which can also cause irregular cycling before pregnancy v) PCOS - Insufficient vitamin B2, leads to lower conversion of testosterone to estrogen, with elevated testosterone and lower estrogen levels