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As a fatty acid amide, PEA interacts with the peroxisome proliferator-activated receptor alpha (PPAR-$\alpha$) and G-protein coupled receptors to down-regulate mast cell activation, offering an advanced model for studying the mitigation of visceral pain and chronic neuro-inflammatory signaling along the enteric nervous system
References (1) Pissios P
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In many cases, these studies involve small groups of healthy volunteers
Diella G, Di Ciaula A, Lorusso MP, Summo C, Caggiano G, Caponio F, Montagna MT, Portincasa P (2018) Distinct effects of two almond cultivars on agreeability and gastrointestinal motility in healthy subjects: more than mere nutraceuticals
