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Samuels, a professor at the Oregon Clinical and Translational Research Institute, stated: It is a common clinical observation that some otherwise healthy patients with hypothyroidism continue to complain of fatigue, poor mood, inability to concentrate, and vague cognitive difficulties (often described as brain fog) despite normal TSH levels. [5] 2

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Changes of pulsatile GH secretion profile need to be investigated, probably using the animal models with selected circadian clock gene knock-out