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Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance
Subcellular Hsp70 inhibitors promote cancer cell death via different mechanisms
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regulating thyroid function
The future obesity treatment landscape will likely evolve into a more personalized and tiered approach, with oral therapies supporting treatment initiation, maintenance, and convenience-focused use cases
TRIUMPH-3 Results in Detail TRIUMPH-3 enrolled 1,949 adults with severe obesity (BMI 35) and established cardiovascular disease, with or without type 2 diabetes, randomized 1:1:2 to retatrutide 9mg, 12mg, or placebo over 80 weeks
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