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Will taking both medications increase my risk of side effects
Recent studies using tissue/cell-specific gene knockout mouse models and cell culture techniques have clearly demonstrated that locally produced IGF-I is more critical than the systemic IGF-I in supporting embryonic and postnatal skeletal development and bone remodeling
(PubMed) Eussen SJ, Ueland PM, Clarke R, et al
Self-monitoring of blood glucose is particularly important for patients on concomitant insulin or sulfonylureas, as GLP-1 therapy may necessitate dose reductions of these medications to prevent hypoglycemia
Additionally, lixisenatide was associated with fewer gastrointestinal symptoms compared to exenatide, while long-acting GLP-1RAs generally caused less nausea and vomiting but more diarrhea than short-acting agents (49)
46 Thus, pharmacological inhibitors, blocking antibodies and knockdown of PI3K abolishes the insulin stimulation of glucose transport, GLUT4 translocation and DNA synthesis
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