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Am J Surg 1993
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45(8): p
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When a very large dose of paracetamol is taken, glucuronidation capacity is saturated, more of the minor metabol ite is formed hepatic glutathione is deplete and this metabolite binds covalently to proteins in liver cells (and renal tubules) causing necrosis
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Researchers should interpret the cited literature within the experimental context of each individual study
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Galvano, F., Li, Volti G., Malaguarnera, M., Avitabile, T., Antic, T., Vacante, M., and Malaguarnera, M
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