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Limitations of This Comparison Several structural limitations constrain everything above, and honest readers should keep them in view: Species and model gap
Observed Side Effects (From Clinical Trials) In the Lancet 2021 Phase 2 trial (n=706), at the highest 4.5 mg/week dose, 88% of participants reported at least one side effect and 63% reported a GI-specific event
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How Joint Pain Affects Daily Life Reduced Mobility: Pain and stiffness can make everyday tasks more challenging
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