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After thorough safety and efficacy evaluations, along with in vivo and in vitro model studies, the most promising antifungal compounds in preclinical and clinical development include novel triazoles, glucan synthase inhibitors, and small-molecule polypeptides

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In addition to complex I deficiency patients, riboflavin administration has been used in complex II deficiency patients, resulting in moderate clinical improvement, stable clinical picture, and prevented disease progression, as well as a twofold elevation in complex II activity in vitro (48)

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But a research protocol using denatured peptides will show no results, and you won't know whether the failure was the peptide, the protocol design, or your reconstitution technique