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Adoro et al., 2015
A control reaction was performed in the absence of substrate
The study demonstrated that Semax significantly increased 5-HIAA in the striatum raising tissue content by roughly 25% and extracellular levels up to 180% over 1-4 hours indicating a positive modulatory effect on the striatal serotonergic system
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Its oral bioavailability is achieved by incorporating the absorption enhancer SNAC (Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate), which works through two mechanisms: (1) temporarily raising the local pH in the stomach to reduce pepsin-induced degradation of the peptide drug, and (2) forming hydrophobic ion pairs (HIP) with the peptide drug, improving its membrane permeability
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