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Some patients also notice an upset stomach, nausea, constipation, diarrhea, or a heavy, full feeling, especially at the beginning or with higher doses
Science 356 , 11881192 (2017)
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PMID: 21530563
Central nervous system mediation occurs through GLP-1 receptors in the hypothalamus and brainstem, particularly the area postrema and nucleus tractus solitarius [8]
Long-Term Effects: As a relatively new drug, the long-term effects of prolonged Ozempic use are still under investigation
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