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If your genetics suggest lower GLP-1R sensitivity or increased nausea predisposition, your provider can recommend tirzepatide or oral formulations that may cause less discomfort
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It may be easier for most people to make a transition when switching from tirzepatide to semaglutide since they are moving from a two-hormone formulation (GLP-1 and GIP) to a single-hormone formulation (only GLP-1)
doi:10.1615/critrevtherdrugcarriersyst.v20.i23.30 70
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