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A reduction in GSH levels was also found, which could be both, cause or consequence of the decrease in GPx and GR activities

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Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety

Examining both within one experimental system lets researchers compare convergent versus independent signalling

Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine

Disorders of Glutamate/Glutamine and Aspartate/Asparagine Metabolism Aspartoacylase Deficiency Aspartoacylase (ASPA) deficiency, also known as Canavan disease, is caused by mutations in the aspartoacylase gene and leads to a high accumulation of N-acetylaspartate (NAA) and its derivative N-acetyl-aspartyl-glutamate (NAAG) in the brain [91]