Weight loss and improved insulin sensitivity reduce hyperinsulinemia and increase SHBG, thereby lowering free androgen exposure and decreasing ovarian and adrenal androgen production
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At physiological levels, they serve as signaling molecules that promote exercise-induced adaptations, such as mitochondrial biogenesis via PGC-1 and upregulation of intrinsic antioxidant systems
Walmart, for example, which sells Ozempic and other GLP-1 drugs, found that customers buying those medications spent less on food year over year but more on lifestyle and fitness
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