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Nevertheless, differences in baseline clinical characteristics between trial participants and real-world populations may still influence generalisability, particularly as the trial was not powered to detect subgroup differences

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With insurance, those drugs cost about the same as a typical meal at a restaurant which sounds less appealing on those appetite-suppressing drugs anyway

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For more info on this trial including clinical perspective, CPP members can see the September 2025 Critical Care Pharmacotherapy Literature Update on SCCM Connect here: #PharmICU #CPPPLU To view or add a comment, sign in Editorial: Decades after statins revolutionized lipid management, the CORALreef HeFH trial demonstrated that oral enlicitide achieves robust, sustained reductions in LDL-C and other atherogenic lipids in patients with heterozygous familial hypercholesterolemia already receiving statin therapy