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IBD is associated with the dysregulation of the symbiotic relationship between the commensal ecosystem and the mucosal immune system ( Crohns disease (CD) and ulcerative colitis (UC) are the two major phenotypes of IBD, and they differ meaningfully in their biology, barrier injury patterns, and epithelial restitution mechanisms

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They are dense, collagen-rich tissues with fewer blood vessels

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Retatrutides approach of adding glucagon activation to established GLP-1 and GIP effects opens metabolic possibilities that werent available even three years ago