Then glutamate is converted into -ketoglutarate (-KG), an intermediate of the TCA cycle, by glutamate dehydrogenase to compensate for the deficiency of glucose metabolism and OXPHOS [176]
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"Alia Bhatt's 'real friendship' with dad Mahesh began after she became an actress"
Ismail MF, ElMeshad AN, Salem N-H
As the most abundant free amino acid in circulation, it serves as a major metabolic substrate for rapidly proliferating immune cells, sustains intestinal barrier integrity, assists in nitrogen transport, and contributes to acidbase homeostasis (Newsholme, 2001)
It occupies a scientifically legitimate space between those extremes: a peptide with a plausible endogenous origin, a well-characterized set of molecular targets, and an unusually consistent preclinical record across diverse injury models and species