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Hydration and gradual dose escalation may minimize this concern
Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H
PMID: 42 RauMSchillingA-KMeertensJHeringIWeissJJurowichCet al
For many patients, their injections dont last long enough Some clinicians assume (incorrectly) that 1000 mcg of B12 should last patients at least 200 days, calculating from a 5 mcg daily requirement for the vitamin
Oron 2014)
However, it is generally used in cycled protocols (e.g., 8-16 weeks) rather than continuous long-term therapy
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