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In animals, atenolol is well distributed into most tissues and fluids except brain and /cerebrospinal fluid/

Onset: gradual

Journal of Clinical Endocrinology & Metabolism, 95(7 Suppl 1), S1-S66

Whilst the concentration of melatonin used in vitro far exceeds that found in vivo , in vitro conditions lead to the rapid degradation of melatonin reducing its concentration swiftly over a 24h period

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