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Drug Interactions and Concomitant Therapy Considerations 7.1 Interactions with Cardiovascular Medications Increased hypotensive effect when combined with ACE inhibitors or diuretics Risk of bradycardia with other beta-blockers or digoxin 7.2 CNS and Antidepressant Drug Interactions SSRIs such as paroxetine may inhibit metoprolol metabolism

Frequency-dependent oscillatory shear testing demonstrated that both formulations exhibited predominantly solid-like viscoelastic behavior, with storage modulus ( G ) exceeding loss modulus ( G ) over all observed frequencies, and tan( ) values between 0.1 and 0.5 across the entire frequency range, indicative of robust physical cross-linking and structural integrity essential for depot formation ( Figure 2B , E )