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A number of studies have demonstrated sustained weight loss post-medication removal
The body's tolerance to semaglutide's effects typically stabilizes around the 1012 week mark
An October 2024 review from the American Heart Association cited two recent studies showing that less than half of the weight lost from GLP-1 medications came from fat, with a substantial portion coming from muscle mass
Over time, the central nervous system itself becomes sensitized
For most candidates, GLP-1 therapy represents a favorable risk-benefit profile when monitored appropriately
Ann Surg 240:236242 Salehi M, Vahl TP, DAlessio DA (2008) Regulation of islet hormone release and gastric emptying by endogenous GLP-1 following glucose ingestion
