In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain
Yes, Semaglutide can be taken long-term in order to maintain weight loss
Initiation of a GLP-1 receptor agonist was associated with reduced risk of composite endpoint of all SUDs (hazard ratio 0.86 (0.83 to 0.88), NRD 6.61 (7.95 to 5.26)) (fig 3, fig 4 and supplementary table S6)
3 GLP-1R localization and mechanistic pathways in metabolic and behavioral regulation GLP-1 Rs exhibit high expression in pancreatic -cells in both rodents and humans, where they play a pivotal role in mediating glucose-dependent insulin secretion (Nauck et al., 1993
As with any medical treatment, however, it is important to understand how your body may respond before beginning the journey
Presented for research literature review only Launay JM et al